MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

MmpL Proteins in Physiology and Pathogenesis of M. tuberculosis

Blog Article

Mycobacterium tuberculosis (Mtb) remains an important human pathogen.The Mtb cell envelope is a critical bacterial structure that contributes to virulence and pathogenicity.Mycobacterial membrane protein large (MmpL) proteins export bulky, hydrophobic substrates that are black knight darts essential for the unique structure of the cell envelope 20wm01snus and directly support the ability of Mtb to infect and persist in the host.This review summarizes recent investigations that have enabled insight into the molecular mechanisms underlying MmpL substrate export and the role that these substrates play during Mtb infection.